This does not sound good. Responsible owners are careful about staying in touch with their guests. Have you contacted the customer service department at the website where you originally found the listing, e.g. Homeaway.com or VRBO.com? The customer service people can tell you if the original owner had his or her mail hacked -- which often results in the web site taking down the listing. If they haven't heard of any problems, they can try to contact the owner directly.
Since you paid through PayPal, you have some recourse and can to get a charge back through them.
Good luck, and post again here when you figure out what is going on.